Cytori Therapeutics reported results from a preclinical study on the use of uncultured adipose-derived regenerative cells (ADRCs) in treating critical periodontal defects in a rat model.
The results suggest that the use of ADRCs may reverse the effects of periodontal disease, evidenced by significantly improved alveolar bone healing and decreased gingival (gum) invasion of the defect, the company said.
The data were reported at the American Academy of Periodontology annual meeting in Boston.
As part of the study design, 20 immunodeficient rats were each treated for four critical defects. One of the defects was treated with uncultured human ADRCs and a second with cultured human adipose-derived stem cells (ADSCs), both in platelet-rich plasma (PRP). A third was treated with PRP alone and a fourth was untreated.
At six weeks post-treatment, the defects treated with the uncultured ADRCs and the cultured ADSCs showed a statistically significant improvement in healing of the alveolar bone compared to the two controls, according to Cytori.
Furthermore, uncultured ADRC and cultured ADSC treatment significantly decreased the gingival invasion of the defect when compared to no treatment and PRP alone.
These new study findings may lead to new therapeutic treatments using ADRCs to treat and potentially reverse the effects of severe periodontitis, Cytori said.
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