Exposure in the womb to bisphenol A (BPA) causes changes in female primates' uterus development, new research suggests. The results were presented this week at the Endocrine Society's annual meeting in Boston.
BPA is a synthetic, manmade chemical with estrogenic properties that is used in a variety of products, including dental sealants. In animal studies, exposure to BPA early in life has been shown to prompt various abnormalities in the early development of the brain, behavior, prostate gland, and breast tissues.
"Previous studies have shown that BPA can affect the reproductive tract. However, because the studies were done in rodents, it was uncertain if this would also be true in humans," said study co-author Carmen Williams, MD, PhD, a clinical investigator with the National Institute of Environmental Health Sciences (NIEHS).
The new study used the rhesus monkey, a species that is very similar to humans in regard to pregnancy and fetal development, according to Dr. Williams.
She and her colleagues conducted the research at NIEHS and the California National Primate Research Center in Davis, which cofunded the study with the NIEHS. During a period that represented the third trimester of human pregnancy, the investigators gave BPA to 12 pregnant monkeys, each carrying a single female fetus.
In the first year of the experiment, six monkeys received BPA orally in a fruit treat, at a dose of 400 micrograms per kilogram of body weight daily, the researchers reported. During the second year, six additional pregnant monkeys received BPA through capsules implanted subcutaneously, for a daily dose of 100 micrograms per kilogram. Both forms of BPA resulted in a BPA level in the blood that is close to levels normally found in adult women, according to the authors' abstract.
The investigators analyzed the uterus of each offspring for gene expression. Oral BPA altered expression of HOX and WNT genes that are critical for uterine development, they found. They are still analyzing the data for the animals that received subcutaneous BPA, Dr. Williams said.
Differences also appeared in the extent of development of the cells lining the uterine cavity in BPA-exposed animals but not in a control group of unexposed monkeys.
"This research supports the recommendation that pregnant women should limit their exposure to BPA," Dr. Williams said.
