AddBio has developed Zolidd, a bioactive nanolayer that improves the stability of dental implants.
A randomized clinical trial conducted at Linköping University Hospital in Sweden showed that dental implants with a bisphosphonate nanolayer have improved stability, according to the company.
After surgery, it may take several months for the bone around the implant to heal and become strong enough for the patient to regain normal chewing function.
Developed by Per Aspenberg, MD, PhD, and Pentti Tengvall, PhD, of Linköping University, Zolidd is the first application from a technology designed for local release of drugs from medical implants.
A nanometer-thin protein layer is attached to the metal surface and a bisphosphonate is attached to the protein. When the bisphosphonate is released, the local effect improves implant stability.
In the study, a Zolidd prototype was used to release bisphosphonate. Sixteen patients each received two implants, one with bisphosphonate and one without. After six months, the bisphosphonate treated implant showed improved stability in 15 out of 16 patients.
X-rays showed positive effects on the treated implants after two months. No complications occurred.
